The Violets (16-2, 5-2) scored the first five points of the game, raced to an 11-2 lead, and went up by as many as 22 points in the first half before settling for a 38-17 lead at the break.
It was more of the same in the second half, as the Violets stretched their lead to a game-high 40 points, 76-36, on junior Chael Clark's layup with 6:04 remaining.
In another display of accuracy for NYU, the Violets shot 57.4% (31-54) from the field. In Friday's 97-64 win over Emory, the Violets shot 66.7% (36-54).
A quartet of Violets scored in double figures.
Junior Michael DeCorso led the way with 19 points followed by junior Jason Boone (16), junior Matt Basford (10), and senior Jared Kildare (10). Boone also had eight rebounds and two blocks, while Kildare contributed nine assists and two steals. Sophomore Michael Magee also had eight rebounds, tying his career high.
Mason Conrad led Case Western Reserve (10-8, 2-5) with 13 points. The Spartans were held to 29.4% shooting in the game.