Matt Harrison scored 45 points for Benedictine as he made eight 3-pointers to hand the Muskies their first loss since December 28 against than #7 ranked Hope College, 54-46.
Senior Germayne James led Lakeland with 20 points, while freshman Matt Rogers added 19. Sophomore Danny Ehnert was the only other Muskie to score in double figures with 10.
Lakeland shot just 46 percent from the field, while Benedictine shot 49 percent.
The Muskies, 17-5 overall and 11-1 in the Lake Michigan Conference, will travel to Maranatha on Saturday for an LMC match-up before hosting MSOE on Feb. 11.