The win marked the 100th for Head Coach Mike McGrath during his seven-year tenure at Chicago. McGrath now stands at 100-56.
Chicago trailed 37-35 at the intermission, but held the White Mules to 16 points and 21.7% field goal shooting in the second stanza.
Colby led 53-52 with 4:26 left in the game before the Maroons closed out the contest with an 11-0 run. A pair of free throws by Brandon Woodhead gave Chicago the lead for good, 54-53, at the 3:52 mark.
Nate Hainje added 11 points for the Maroons.
Andy Jenkins paced Colby with a game-high 18 points.