Claire Getzoff scored 19 points to pace Lawrence (10-2, 4-1 MWC). Jenny Stoner added 10 points and was one of 14 Lawrence players to score.
Lindsay Fondow led Knox (2-9, 0-5) with 10 points.
Knox kept it close for most of the first half, but the Vikings went on a 16-3 run in the final 4:57 of the first half to grab a 46-21 lead at the break.
Lawrence never looked back and led by as many as 39 points in the second half.
Lawrence limited Knox to 32.1 percent shooting (17 of 53) from the floor, and the Prairie Fire hit only 9 of 22 (40.9 percent) free throws. The Vikings shot 52.8 percent (28 of 53) from the floor.