St. Clair added 15 rebounds for the Chargers (2-1), who also got 17 points from Chris Condon and 16 from Pat Kenny, 12 coming off four three-pointers.
The Chargers out-rebounded the Panthers of Plymouth State, 46-30, helping Colby-Sawyer overcome a four-point halftime deficit. Andreas Pope scored 21 points to lead Plymouth State (2-2), while Nick Pelotte added 15 points.
Colby-Sawyer will open Commonwealth Coast Conference play on Saturday with a 3:00 p.m. game at Nichols.