Buffalo State’s Justin Konst connected on three of his four 3-point shots during the run.
Plattsburgh State (7-9, 3-6) cut the lead to a single point twice in the final three minutes but each time the Bengals converted their next possession.
Curtis Smith led the Cardinals with 16 points, four assists and four steals while Cameron Arterberry added 15 and Johnny Carter scored 11 points and grabbed 12 rebounds.
The Cardinals continue SUNYAC play with a road trip to New Paltz Friday night and Oneonta State Saturday afternoon.