Smith led the Cardinals (6-8, 2-5) with 16 points. Cameron Arterberry added 11 points and a team-high eight rebounds while Brian Hatch chipped in 10 points for Plattsburgh.
With Fredonia up two in the closing seconds, the Cardinals did not attempt a shot as several players scrambled for a loose ball under the Plattsburgh basket.
The Cardinals return home for a 7 p.m. non-conference game Tuesday against Paul Smith’s College.