After a Knox shot crawled to along the rim and fell back off, Elyse Lambert made a huge hustle play, digging the defensive rebound off the floor, and Courtney Scherrer made a free throw at the 15-second mark for a two-point lead. Knox then missed two game-tying shots in the final seconds.
Monmouth scored the last seven points of the first half to go up 26-24, and the Scots' lead reached as high as eight points before Knox went on a 6-0 run to take the lead with 3:33 to play.
Lisa Curry had a career-high 18 points and nine rebounds for MC, which finishes 6-17 and 4-12,
and Laura Jahn added 11 points. Hillary Nelson had 13 points and three steals for Knox, which lost its 15th straight game.