Colby-Sawyer also got 21 points from Pat Kenney and 19 points from Chris Condon as they improved to 3-1 on the year and 1-0 in the Commonwealth Coast Conference.
The Chargers forced 12 Nichols turnovers, while only giving the ball away seven times themselves. Colby-Sawyer also hit 15 three-point shots at a pace of 42.9 percent, while the Bison went 0-17 from beyond the arc for the game.
Anthony Smith led Nichols (1-3, 0-1) with 14 points, while Justin Lewis added 13.
Colby-Saywer returns to action on Tuesday, November 8, when they travel to the University of New England for an 8:00 p.m. contest against the Nor'Easters. The Chargers return home two days later to host Bowdoin at 8 p.m.