Senior guard Jenna Pratte led Waynesburg with 12 points, along with nine rebounds, while Michaelene Jones paced all players with a career-high 14 rebounds (five offensive).
Senior Katie Lewandowski gave Waynesburg an 8-2 lead at the 15:49 mark, but the Yellow Jackets (2-2) would fail to score for over the next nine-plus minutes. SUNY-Oneonta scored 12-straight points to take a 14-8 lead during that span.
Jones cut the deficit to 18-17 with 2:18 left in the half, but the Red Dragons closed the half on a 7-1 run to take a 25-19 lead into intermission.
SUNY-Oneonta took a nine-point lead early in the second half before freshman Johnna Deco hit a jumper with 13:50 left in the game, 32-25. The Yellow Jackets went cold from the field and struggled with turnovers, going six-plus minutes without a point. The Red Dragons took advantage of the Waynesburg struggles, going on a 15-0 run to take a 47-25 lead.
Waynesburg shot 31.1 percent (15-of-48) from the field, while SUNY-Oneonta shot at a 35.6 clip (21-of-59). Despite the loss, the Yellow Jackets held a 44-31 advantage on the class, but committed 37 turnovers.
Gurad Sara Chrystie led the Red Dragons with 11 points off the bench, while forward Shannon Weir nearly registered a double-double with 10 points and nine rebounds.