Tanesha Hughes' third basket in a five-possession stretch cut DePauw's lead to 42-28 late in the first half, but the Tigers headed into the locker room on a 7-0 run and then scored the first five points of the second half to go up 54-28. Monmouth would get no closer than 19 points the rest of the way.
Hughes had a season-high 16 points off the bench for the Scots, who were led by Melissa Gorski's 19 points.
DePauw point guard Suzy Doughty was all over the court, making 10 steals and dishing out 10 assists to go with nine points.