With the win, the Lady Crusaders earn the series sweep and improve to 7-8 on the year.
Millsaps blew a 12-point first half lead and were outscored 37-20 in the second half en route to its 10th loss of the season to just two wins.
The Majors held a 36-29 edge heading into the locker room, but a furious 20-5 run from the University of Dallas to open the second half gave the Lady Crusaders a 49-41 lead that they would never relinquish.
Senior guard Kristy Malone sparked the Dallas run, scoring 10 of her 14 points in that span by knocking down a pair of 3-pointers, a jumper and a layup.
After shooting close to 42 percent in the first half, the Majors shot a dismal 21 percent from the floor in the second half, only knocking down six total field goals in the period.
LaReina Adams scored all 12 of her points in the second half and came two rebounds short of her eighth double-double of the season before fouling out with 7:13 remaining in the game.
Deborah Sturgis picked up her second double-double of the season with a 15 point, 11 rebound performance, while Marianne Smith had 14 and Crystal Dickerson added 12.
The Majors will be back in action on Friday and Sunday, playing host to conference opponents Oglethorpe and Sewanee.
Friday's game tips off at 6 p.m. with Sunday's game slated for a 3 p.m. start live on ESPN Radio 1240AM with broadcaster Derrel Palmer.